CO885-(20-21) — Page 48

Three Calces. All infected by inoculation.

Calves A, B, and E., treatment a failure in all three. Two already dead; one living, but condition not hopeful.

Two Oxen Nos. 1 and 2.-Both cases of natural infection. In case of No. 1, the disease was much advanced when the case was taken in hand, and the result of treatment was unsuccessful. The animal died on the sixth day of treatment. In the case of No. 2, the disease was not so far advanced as in No. 1, but the treatment proved a failure and the animal died after the treatment.

11. I regret that I have not been able to test the treatment more fully on horses. as their cost is prohibitive. Further experiments should be conducted on horses, as I have already said under my remarks on page 48.

12. In conclusion I wish to say that I am greatly indebted to Major McClintock, the Resident, for the invaluable aid he has afforded me by providing me with most of the animals experimented on and the cost of maintaining them to a great extent, as well as helping me in many other respects in connection with the work, for which I wish to take this opportunity of expressing my thanks to him. I have also to thank Mr. Elder, the Assistant Resident, for the help he has also given me in furthering the work.

H. ANDREW FOY,

Maiduguri, January 1st, 1908.

Enclosure 2 in No. 21.

Medical Officer.

A SECOND REPORT* ON EXPERIMENTAL WORK ON ANIMAL TRYPANOSOMIASIS, CONDUCTED AT MAIFONI, SOUTH BORNU, FROM SEPTEMBER, 1907, TO OCTOBER, 1908, BY H. ANDREW FOY, Medical Officer, West African Medical Staff.

CONTENTS.

1. Normal temperatures of animals

2. Incubation periods in animals

3. Invasion of the disease

4. Strains of trypanosomes used in the course of experiments -

5. Blood-sucking flies in South Bornu

6.

The experiments conducted begin on

Section 1. on the treatment by the mixture of methylene blue and

chloride of mercury

Animals experimented on in Section I.:

Page

X

8

N

9

9

10

per-

10

10

51

Summary of results attained under Section 11. Recommendations

Further experiments to be conducted Section III, experiments on immunity Animals experimented on in Section III.

Page

19

20

20

20

Dog H Dog M

20

Calf L

21

Dog J

22

Calf J

22

Dog T

23

Dog U

23

Dog W

23

Dog V

24

Dog N

24

2-1

Special series of cases :-

A. Injected with blood-

Horse H...

Calf K

Dog Q Dog R

Monkey A

B. Injected with blood serum-

Horse I

Calf M Dog S

Monkey B

Summary of results attained in Section III. Factors which lower virulence of a strain

Degree to which virulence of strain is lowered Further experiments to be conducted Recommendations

Conclusion

25

25

26

26

26

**NN NARAAA

26

26

27

Horse B

Dog E

Calf D

Calf E

Dog G

12

Dog I

12

Summary of results obtained under Section 1.

12

==="ཁ

Animals experimented on in Section II. :-

Section II., on the analysis of the therapeutical value of each of the in-

gredients used in Section 1.

12

12

Horse C

Horse D

13

Dog L

Dog O

Horse E

13

14

15

Dog K

Horse F

15

15

Horse G

Calf I

Calf F

Calf C

Calf G

18

Calf H

18

Dog

18

50 50

The charts accompanying the report are not reproduced.

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16

16

17

17

PUBLIC RECORD OFFICE

Reference :-

TTTTT C.O. 885

| | | | | | | | | | | | | | | |π

20 PUBLIC RECORD OFFICE, LONDON

ALLY WITHOUT PERMISSION OF THE BE REPRODUCED PHOTOGRAPHIC- COPYRIGHT PHOTOGRAPH—NOT TO

+

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30

30

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Report II., on the Treatment of Experimented Trypanosomiasis that was begun at Maifoni, South Bornu, in September, 1907, and was continued during 1908. Report I., on the result obtained up to 31st December, 1907, was submitted previously in January, 1908.

1.

Normal Temperatures of Animals. As complete temperature charts of cach case experimented on are again being submitted for the sake of reference, the normal temperatures run by horses, oxen, calves, dogs, and monkeys have again been given in the form of charts, which will be found attached. The daily variations in the normal temperatures of these animals, as struck from observations made, were as follows:-

(a) Horses, 98° to 100° F.

(b) Oxen, 97° to 102.4° F.

(c) Calves, 97° to 102.6° F.

(d) Dogs, 97° to 102.4° F.

(e) Monkeys, 97° to 102° F.

Incubation Periods.-The following periods of incubation of trypanoso- miasis in animals, after subcutaneous inoculation, have been struck from observa- tions made in the course of experimental work conducted :—

(1) Horses, 3 to 14 days (struck from seven cases).

(2) Calves, 4 to 13 days (struck from eight cases).

(3) Dogs, 8 to 12 days (struck from five cases).

Monkey, 9th day (according to information obtained from Mr. Brand).

3. Invasion of the Disease.-In the case of each of the animals from which the incubation periods have been struck, the onset of the disease after inoculation

was marked by a rise of temperature, which took the form of either a sudden

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