504

the walls of the ileum. The Peyer's patches were swollen and inflamed, or were surrounded by, haemorrhages. the glands in the mesentery varied in their appearance. In many instances the changes amounted to enlargement and congestion.

with

In other cases

they were softened and contained haemorrhages, and serous fluid, and as such combined, form a distinct bubo.

These Experiments appear to show that

plague in its various forms may be produced in Guinea Pigs by feeding

the

cultures of the

with

agar-agar

pestis. Young cultures call forth the disease with greater uncertainty than cultures of greater age. Young culture

usually

would appear to produce the bubonic or septic types of the

the disease. Older cultures,

however, very frequently set up typical intestinal plague with a mesenteric bubo.

Series, NETIL. II Feeding.

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