10
guinea pigs was practically the same throughout. The virulence different cases
N
the bacillus in
498
of human plaque, when tested on guinea pigs did not appear to vary much. In general, the guinea pigs died in from 3-6 days after inoculation.
The post-mortem lesions found were chiefly of generalized congestion and inflammation of the organs and tissues with haemorrhages and degeneration. Buboes in the neck, axillae and groins are also found either alone or with intestinal changes, and vice versa. In animals showing typical intestinal plague, the changes found in the abdominal cavity were striking. Haemorrhages are scattered throughout the contained viscera. The Peyer's patches & lymph follicles are swollen, may be ulcerated. They may be haemorrhagic like the wall of the gut. The Mesentery shows enlarged glands with general congestion and frequently the presence of a distinct and well-developed bubonic formation. Cultures and smear preparations from the intestine