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October 7th, 1904.-The pig was fed with an emulsion composed of the whole brain of a Beri-beri cadaver mixed with boiled rice. The brain was obtained from a freshly dead case and emulsified within one hour after death.
The animal ate voraciously, having been kept without food for 24 hours previously.
The attached temperature chart shews that during the experiment there was no fever.
October 17th, 1904.-The animal died to-day rather unexpectedly. Up to the date of its death, it never shewed any signs of Beri-beri infection. There was no epigastric tenderness, no ædema, and no disturbance of locomotion and sensation. During the greater part of the time the pig was dull and refused food. It became progressively weaker.
Post-mortem Examination—No sign of Beri-Beri. No gastro duodenitis.
No ædema. Heart normal.
Cause of Death.-Chronic cachexia, the result of ptomaine poisoning.
[On October 15th, 1904, was again fed with internal organs of pig of Experiment No. I.]
Experiment No. V.
Animal-One pig.
Preliminary precautions, and the animal's condition carefully noted.
previous to the commencement of the experiment.
October 25th, 1904.-To-day the animal was fed with the emulsified brain of an acutely fatal case of Beri-beri. The brain was obtained within two hours of the death of the patient. It was broken down and mixed with boiled rice and water and then given to the animal, which consumed it entirely.
November 1st, 1904. Another brain was obtained from a similar case, treated exactly as before and eaten by the pig.
On the following day an examination of the animal shewed nothing of note. It ate well, had no diarrhoea, moved about in a normal fashion, and had no tender- ness over any part of the body surface. There was never any rise in temperature.
November 5th, 1904. The pig died to-day, and post-mortem examination shewed the cause of death to be a form of hæmorrhagic septicania. There was no evidence of Beri-Beri.
Experiment No. VI.
Animal-One pig.
Preliminary precautions were taken as in previous experiments.
October 25th, 1904.-The animal was fed with an emulsion composed of boiled rice, water, and broken down liver substance, and one pint of the blood of a well marked Beri-beri cadaver. The organs were obtained almost immediately after death and the pig fed at once.
October 27th. 1904.-The animal appears to have lost its appetite, but has no vomiting or diarrhoea. There is no apparent surface tenderness over the body. The legs, especially the posterior pair, appear to be weak. They lock somewhat on forward progression, and the feet are not firmly planted on the ground. The legs are not tender however, and there is no sign of oedema. The knee-jerks were present.
A temperature chart is not attached. The temperature was noted daily and shewed no variation from the normal.
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