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On the 11th October, at 3 p.m., the animal was fed with freshly drawn blood. 40 c.c. was swallowed. The temperature was 102° F., i.e., practically normal for this animal. From the attached temperature chart it will be seen that during the following 5 to 6 days a distinct elevation of temperature was noted. During this time, however, the inonkey shewed no signs of discomfort, being bright and lively and displaying a good appetite; the bowels being norinal. An examination of the blood was negative as regards micro-organisms. The other clements of the blood were normal as regards number and nature.
On the 16th October, the animal was examined thoroughly. It could run and jump and was lively, taking its food well with apparent relish. The knee- jerks were normal. Sensation appeared to be normal. No œdema was found and
the animal did not object to pressure over the epigastric region.
On the morning of the 19th October, the animal was again fed with blood from an acute case of Beri-beri. The amount swallowed was about 30 c.c. The technique was the same as that already described.
This feeding was followed by a slight rise in temperature which continued until the 10th November, when the temperature became steadily 102° of under. The oscillations of temperature were slight during this period, the fever rarely exceeding 103° F.
During this period, i.e., from the 16th October to the 16th November, the animal remained in perfect health. It never showed the slightest disinclination for food. There was no diarrhoea or loss in weight and the motor and sensory apparatus appeared normal after repeated examination.
After the 16th November the temperature and the condition of the animal were noted until the beginning of February, 1905. The temperature remained steady between 1015 and 102° F. The condition of the animal remained good. No evidence of disease was at any time found present. At the present time (October, 1905,) the animal is alive and well, ie., one year after the commencement of the experiment.
Experiment No. II.
Animal-One monkey.
Nature of experiment :—
The animal was fed with an emulsion of the Medulla, and Pons
Varolii obtained from a recently dead case of Beri-beri.
The usual preliminary precautions were observed as regards the
animal, and the temperature was noted daily.
For one month the animal remained in perfect health. There was no rise in temperature, no epigastric tenderness, no loss of knee-jerks, and no paralysis.
About five weeks after the commencement of the experiment the animal con- tracted dysentery from which it died after about 7 days' illuess.
Post-mortem examination :--
Cause of death-Acute bacillary dysentery.
No evidence of Beri-beri.
Experiment No. III.
Animal-One monkey.
Nature of experiment:-
Feeding with freshly drawn defibrinated blood of an acute case
of Beri-beri.
The technique was the same as that described in Experiment No. 1 (above).