medicine and enhance the curing effects. The method of RIA is
an effective means for monitoring the density of drug in the
blood of the patients.
Some drugs with low therapeutic ratio (e.g. cardiac glyco-
side and anti-arrhythmia drugs) must undergo blood-drug monitoring
to guarantee safety in using drugs. In clinical use, digoxin is
a very effective remedy for heart failure, arrhythmia and
paroxysmal tachycardia.
-
However, its density in the blood must
state.
as to maintain the optimum state.
be kept at 0.6 1.6 mg/ml so
In case the density exceeds 2 mg/ml, poisonous by-reaction would
appear (e.g. heart-fury arrhythmia):
Likewise, gentamicin can
kill the gram-negative bacillus and positive coccus when its
density in the blood is 4 micrograms/ml.
However, when the
density exceeds 10 microgram/ml, the result is renal failure,
hearing failure or deafness on the part of the patient.
Furthermore, a kind of anti-epilepsy drug, phenytoinum,
natricum has satisfactory curing effects when its effective
density is kept at 8-20 micrograms/ml. When the said density
is over 20 micrograms/ml, the result would be tremor of eyeball,
dysphonia, etc.
MTX can clinically be used to treat certain kinds of
cancer (chorion-epithelioma, subacute hudatid mole, cancer of
alimentary canal, leukaemia, cancer of lung, etc); but an over-
P. 8
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