TABLE 4
ADVERSE REACTIONS DURING THE FIRST 6 MONTHS AND THEIR MANAGEMENT
Modification to Chemotherapy
Patients with
CONTROLLED TRIAL OF 6- AND 9-MONTH TUBERCULOSIS REGIMENS
Drugs Terminated
None
Interruption
Total
LO
5
6
(no.)
(%)
(no.) (%) (no.)
(%)
S
N
3 6 3
22-
1
17
10
21
12
18
10
22
12
17
9
13
NO
•
2
ONO
3 34
LO LO 00
0
OOO
OOO
402
2
12
5
3
4
1
1
1
O-O
0
5
11
2
6
1
38 -
1
1
942
521
← | |
- 00
0
1
0
0
100
364
121
210
527
12
237
3 -0
73
6 σ
227
625
3
2
722
2
322
644
12
4
Drugs
SZ
SHZ
эт
0
0
1
1
3
3
1
110
эт
3-3 ~ ~ 3 3oool loll
0
1
O O -
1
5 5 3
1
2+
1
♡ O
000
343
OOO
OO | |
OO | |
Reactions*
Adverse Reaction
Regimen
(no.) (%)
1
N
3
Month of Onset
4
SHZ
50
Any
S3H3Z3
46
S2H2Z2
39
21
2225
29
15
10
6
16
10
7
20
3
SHZ
23
13
Cutaneous
S3H3Z3
11
S2H2Z2
16
6 3 σ
6 9
9
420
4
SHZ
11
Hepatic
S3H3Z3 S2H2Z2
SHZ
16
11
8
Vestibular
S3H3Z3 S2H2Z2
SHZ
14
3
508 2
13
Arthralgia
S3H3Z3
S2H2Z2
352
731
- FO
120
2-0
230
327
331
452
6 σ 6
EN LO LO
1
4
2
1
5
4
262
730
4 O
2
123
2
1
120
SOO
For definition of abbreviations, see table 1.
*
Based on 174 SHZ, 185 S3 H3Z3, and 182 S2H2Z2 patients. *One patient developed exfoliative dermatitis.
*Defined in text. Only 1 patient (S3 H3Z3) had jaundice.
731
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