1929-02-14 — Page 11

THURSDAY, FEBRUARY 14, 1929.

K. M. A.

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DAILY CROSS-WORD PUZZLE.

(This cross-word puzzle has been made by an expert but our readers are earned to look out for occasional phonetic spellings, such as harbor, plow, and altho.)

O

17

12

13

4 15 他

17

18 19

31

12

13

15

16

18

19

20

21

22

23

24 25 26

22227

78

129 30

·

131

132

33

35

36

37

138

139 140

42

43

44 45 46

47

48

49

150

51

£52

53

154

155

56

34

HORIZONTAL

T-Strifa

4-la present

10-Challenge

11-Anger

12-Verbal

14-Growe old

16-Hurried

16-Dameetfonte

17-Animal flesh (pl)

10-System

20-Came together

21-Rock

24-Pinying card 27-Pubiła nožlace

(abbr.)

28- Dew loosely 31-Buliding for

automobiles 38-Mare moral 34-Mad

35-Western State

(abbr.)

36-AMrmative.

1

©THE INTERNATIONAL BYNDICATE,

HORIZONTAL (Cont.)

37-A nobleman

VERTICAL (Cont). to-Check

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51-Attention 62-A take

[89–Girl's name 64-Send forth |65–Everlasting

58-A corded fabrio

VERTICAL

1-Balary

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B-Reclines

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6-Taut

7-in no manner

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18-Platform 22-Poem

28-Head covering

24-Stir 26-Veblate |26-Time period

|28-Under

29-Pen

30-Goff term

12-Consumed

33-Prohibit

$5-American country

87-Watershed 38-Finer

40-Existed

141-To correct

44.Nominate

45-Drop 40-Place 48-Perceive

180-Accomplice

(The solution of the above cross-word

puzzle 20ill

appear in to-morrow's issue along with a nero cross bord

puzzle.)

MARKET

For

PRE

AT THE

AWARDED PREVERS

-LON

THE CHINA MAIL,

STORY OF QUININE

3

"Dr

four · years ago the! beat might be had for 40s. the pound. Sir R. Talbor ob serving that Febrifuges were prepared which came very near his own, and fearing that least somebody at length might dis- cover it, resolved to buy up all the Quin-quina that he could find in Faris, and the chief towns of England and France" -a wise proceeding on his part.

to the King, and later on received the honour of knighthood at Whitehall. By a patent issued (Continued from Page 3.).

under the Privy Seal dated Aug- Thomson, a merchant of Antust 7, 1678, Sir Robert Talbor werp," Brady, then professor of was granted an annuity of B100, physic at Cambridge, was one of together with the profits and pri- the first to prescribe it, and Willsvileges appertaining to a Physi- observes it as coming into daily Evelyn, in his diary, on August felan-in-Ordinary to the Sovereign. use, but its general introduction seems to have been largely due to 9, 1679, states that he had

"conversed with the Marquis of Robert Talbor, who may be said

the Normandy concerning to have made his name and for-

Quinquina, which the physi About 1675 Peruvian bark was tune by exploiting it as a secret

clans would not give the King at accepted into the domain of re- remedy.

a time when he was in a dangular medicine, and in 1677 it first gerous ague. It was the only appeared officially in the Londoy thing that could cure him (out Pharmacopoeia under the name of of envy, because, it had been "Cortex Peruanus."

Robert Talbor, or Talbot as he was- sometimes called, had a re markable and Interesting career. He was born in 1642, and after leaving school was apprenticed to Mr. Dear, an apothecary of Cam- bridge. Although entered as a sizar at St. John's College for five years, there is no evidence that he ever graduated. About 1671 he settled in Essex to practise medicine, where, he says, “I planted myself near the seaside where agues are the epidemical diseases." In the followl

brought into vogue by Mr. With reference to the prepara- Talbor, an Apothecary) until tions of the drug, mention should! Mr. Short to whom the King be made of Dr. John Huxham, sent to know his opinion of it, who was the originator of the privately sent word to the King, well-known compound tincture of that it was the only thing that cinchona, the formula for which could save his life, and then he published in his "Essay on the King enjoined the physi- Fevers" in 1755, and which was London cians to give it to him, which first included in the they did and he recovered." Pharmacopoeia of 1788. From this it would appear that We are indebted to the French year he published a little book the activa ingredient in Talbor's for the early botanical studies on called "Pyretologia, a rational remedy was more than suspected cinchona. The first attempt to transport any plants to Europe: account of the cause and cure of at that time.

In 1679 Talbor visited Spain, was made, by La Condamine in Agues," in which he makes refer- ence to his secret remedy for the and on his return through France 1748. He was assisted in his fever, and states that it consisted stayed for some time in Paris, pioneer investigations in Peru by of four ingredients, "two indigen- where he soon became a promin-Joseph de Jussieu. who, after

Madame ent personage.

de affteen years of laborious work, ous and two exotic." He alludes Sevigne. alludes to him several was robbed of his valuable col to Peruvian bark as follows:-

times in her "Letters," and re-lection of plants, a circumstance "Let me advise the world to beware of palliative cures and marks, "Nothing is talked of here which so affected him that he lost

but the Englishman and his his reason. especially of that known as

cures." In November, 1680, wher In 1742 Linnaeus established! Jesuit's Powder, as it is given the Dauphin was seized with an the genus Cinchona, and in 1755 by unskilful hands. Yet this

described the species powder is not altogether to be attack of fever, Talbor who had first

made influential friends at Cinchona officinalis, which he so condemned, for it is a noble and safe medicine and if rightly the French Court, was called in named in honour of the Countess prepared and corrected, and ad- and undertook to treat him. of Chinchon.

The reckless manner in which. ministered by a skilful-hand, Madame de Sevigne says, "the otherwise as pernicious a medi-King, Louis XIV, insisted on the natives of Peru collected the Talbor preparing his wine in his bark at this time, often destroying cine as can be taken. Talbor's reputation soon in presence before giving it to the the trees, while making no at- was tempt to plant new ones, suggest creased, and he removed to Lon-Prince." The treatment

the ed that there would soon be a don, where he set up his sign next eminently successful and door to Gray's Inn Gate in Hol- Dauphin soon recovered. Talbor shortage of the valuable drug. a Chevaller, but the This possibility aroused attention born. The results of his treat was made ment brought him rapid success, King, determined to learn his in Europe, and prompted serious and after having cured the daugh.secret, eventually induced him, for efforts to cultivate the tree on a ter of Lady Mordaunt of an at- a sum of 2,000 louis d'or and an large scale in countries where tack of fever, he was summoned annuity of 2,000 livres, to reveal the climatic conditions were ault- to Windsor toe Charles II, who his method of treatment and the able. In 1839 Royle strongly ad- formula for his remedy, which,vocated the introduction of cin- had been seized with the sar complaint. He was fortunate in however, was not to be published chona into India, and after a long delay this was carried out through being able to restore the King to until after his death.

After a further visit to Spain, the efforts of Sir Clements Mark- health, and so secured the royal favour. Talbor was not a licen-where he cured the Queen of an ham, but not, however, before the tiate of the College of Physicians attack of fever, Talbor returned Dutch had commenced the culti- and had no qualification to prac- to London, where he died shortly vation of the trees in Java. tise, so, to save him from attacks afterwards, in 1681, at the early

YESTERDAY'S SOLUTION

The success which attended the

from that quarter, the King caus- age of 40. He was buried at latter enterprise was chiefly due to Charles Ledger, a Londoner el a letter to be written to the Trinity Church, Cambridge.

The formula for his remedy was born in Bucklerabury, whose College, restraining that body from interfering with him in his published in England in 1682 story is not without an element of After travelling in practice in London. On July 27, under title "The English, Remedy romance. 1672, he was appointed physician Talbor's wonderful Secret for South America in the employment Cureing of Agues, and Feavers." of the New South Wales Govern- According to this book he used [ment buying alpacas, he succeeded several preparations of the bark.in obtaining, through a native the The first consisted of a strong in- servant, some seeds of fusion of the bark with a decoc-Cinchona calisaya from Bolivia. tion of aniseed and juice of pars- Owing to the jealousy of the na-] ley, and after a day or two as tives, who became enraged, he much claret wine was to be added. was afterwards so ill-treated that This was allowed to stand for he died from the effects. Ledger eight days and the liquid then sent the seeds to his brother in strained off. He then made an in- England, who first offered them to fusion with the residue of the first the British Government, but the one with equal parts of fresh bark offer was not entertained. He in powder. This was again macer-then sold half of them to a Ceylon ated with more claret for ten planter, and the remainder to the days, and, after being strained, Dutch Government for about £98. formed the wine he generally ad- From these seeds 20,000 plants: ministered. He also used a tinc-were raised in Java, and go the. ture, which he made by macerat-great industry, from which mil- ing two ounces of Peruvian bark lions of money have. since been in eight ounces of spirit of wine made, was founded.

STRE PCOM SCENES

Medal & Diploma

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RATE

R

Red Hackl

WHISKY

IN THE OPEN COMPETITION

AT THE

BREWERS' EXHIBITION LONDON, NOVEMBER, 1928.

PROPRINTORS DAY

HEPBURNE ROSS, GLASGOW.

RED

SIPA

RIE OIRIT

for fifteen days. It is interesting Until the beginning of the nine. to note that this preparation is teenth century cinchona bark was practically the same strength as still used in its crude state, al- the tincture of cinchons of the though several unavailing, at British Pharmacopoeia to-day. To tempta had been made to discover. it he would sometimes add red its active principles. It was not roses, lemon juice, fennel-root until 1810 that Gomez of Lisbon juice, smallage leaves, or parsley, succeeded in unlocking the and, when he thought necessary, secrets of the bark and isolated its a small quantity of tincture of basic properties, which he called opium. These were the prepara- "cinchonino." A few years later tions of cinchona, all excellent of Pelletier and Caventou, the their kind, by means of which French chemists, set out to study Talbor became famous throughout the whole chemistry of cinchöna, Europe,

And in 1820 they were able to During the last illness of prove that the "cinchonino" con harles III the bark was againsisted of two distinct alkaloids, dministered to him twice.. Acone of which they called "quinine" ording to the record, on February and the other "cinchonine. The

$84.

text advance was made by Henry

His physicians hearing that and Delondre, who in 1888 isolat ⚫ species of intermittent fever fed quinidine. This was followed as raging all over the city, by the discovery of cinchonidine which com enced with severe by Winckler in 1844, while Pas- 'convulsiona but which was tour produced the alkaloidal deri- speedily cured by the use of vatives cinchonicine and quinicine. Peruvian bark at intervals, they Since the discovery of quinine all agreed to administer it to thirty, alkaloids have been found the King and draughts were to occur naturally in cinchona prepared of the bark in powder barks, and from these there have with Syrup of Cloves and given been many derivatives. Quinine, in small doses throughout the the most Important of the cin -day "book

chona bases, possesses the most There is an interesting bill in powerful febrifuge properties of the British Museum, dated 1675, in all, and is capable of completely which Dr. Charles Goodal offers neutralizing acids and forming to sell at the "Coach and Horas" crystallizable suits.

in the Physicians' College in War- The sulphate, nt one time so wick Lane RC largely employed in medicine, is superfine sort of Jesuita now being superseded to some ex- bark ready powdered and tent by the more soluble salts, the papered into doses, at 48. per such as the disulphat bunce or £3 per pound, and for hydrochloride and the hydrobro the excellency and efficacy of mide, all of which are much more this ticular Bark enquire of soluble in water.

ton in Grey Verevi Thng briefly in cutline Is the me price:

adrug that

quoted by Gideon Harvey hhả

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