CO885-(21-23) — Page 113

PUBLIC RECORD OFFICE

Reference :-

C.O. 885

22 PUBLIC RECORD OFFICE, LONDON

ALLY WITHOUT PERMISSION OF THE BE REPRODUCED PHOTOGRAPHIC- COPYRIGHT PHOTOGRAPH—NOT TO

{

48

He asked whether the Liverpool School could be induced to abandon the ex- pedition if it were found impossible to send it out in the charge of Dr. Thomas on the basis proposed, and Mr. Read indicated that it might be possible to induce them to do so, but he was unable to say for certain whether this would be the case.

Finally the Committee agreed in reporting to the Secretary of State that they concurred in the importance of further investigations to be carried on in conjunction with the local authorities by an outside investigator, and that if possible Dr. Wolfer- stan Thomas should be chosen for the conduct of the investigation, as his knowledge and standing would insure public confidence in the results which were obtained under his guidance.

They also concurred in the procedure suggested by Mr. Grindle.

30608

(No. 217.)

29130

No. 33.

ZANZIBAR.

MR. CLARKE (Zanzibar) to SIR EDWARD GREY.

(Received September 3, 1912.)

Zanzibar, August 9, 1912. [Published as No. 9 in Appendix 1. to [Cd. 6669], March, 1913.]

No. 34.

NORTHERN TERRITORY OF AUSTRALIA.

RETURN OF MALARIAL FEVER, BLACKWATER FEVER, YELLOW FEVER, FILARIASIS, AND DENGUE DURING THE YEAR FROM THE 1ST JANUARY TO THE 31ST DECEMBER, 1911.

29421

(Received in Colonial Office, September 16, 1912.) [Published as No. 14 in Appendix 1. to [Cd. 6669], March, 1913.]

(No. 313.)

30473

No. 35. JAMAICA.

THE GOVERNOR to THE SECRETARY OF STATE. (Received 17 September, 1912.)

King's House, Jamaica, 27 August, 1912. [Published as No. 3 in Appendix VI. to [Cd. 6669], March, 1913.]

1912.

No. 36.

AT THE

PROTOZOOLOGY REPORT OF

THE

OF PROFESSOR UNIVERSITY OF LONDON FOR THE YEAR ENDING JUNE 30TH,

(Received September 28, 1912.)

[Published us Appendix II. to [('d. 6669], March, 1913.]

30490

49

No. 37.

CEYLON.

REPORT BY THE PRINCIPAL CIVIL MEDICAL OFFICER ON THE USE OF SALVARSAN (606) IN THE TREATMENT OF YAWS. (Received in Colonial Office, September 28, 1912.)

SIR,

Medical Department, Ceylon, Colombo, 28th August, 1912. WITH reference to your letter of 9th instant, I have the honour to forward

a report summarising the work done in the treatment of parangi by Salvarsan in this Island.

2. The treatment was first instituted by Dr. Castellani at the Clinic for Tropical Diseases with good results, then at Anuradhapura in December, 1911, and lately it has been carried on at Batticaloa and Colombo. Dr. W. Shirley Tirimane conducted the experiments at Anuradhapura, Dr. S. Subrahmanyan at Batticaloa, and Dr. R. L. Spittel at Colombo.

3. I will deal briefly with the results in each place and summarise the obser- vations made.

(a) Anuradhapura.-29 cases were treated during the period December, 1911, to 31st July, 1912. In every case the intra-muscular method of injection was employed. The results obtained are "little short of miraculous." Granulomata disappear extremely rapidly, bone pains vanish in about three days after the injection, while deep tertiary ulcers usually heal within three weeks of the injection. The doses of Salvarsan used for adults varied from 0'45 to 06 grammes. Included among the patients were four young children about two years old.

0:10 grammes were administered to each of them. No unpleasant sequela occurred and no visual disturbances were recorded. In one case, however a patient who had not remained sufficiently long in hospital-an abscess formed at the seat of injection, but this healed in less than a week. No relapses have been observed.

(b) Batticaloa.-Twelve cases were treated here during the period under review. The method adopted was :-

A neutral fine suspension of the drug in 15 per cent. sodium hydrate solution (Sp. Gr. 117) and sterile water was made and injected intra-muscularly into the gluteal region, the skin of the part previously being treated with tinct. iodine. The dose injected was 06 grammes for adult males and 0 3 grammes for women and children. After injection the suspension was, by massage, distributed over as large an area as possible and a carbolic dressing applied. The patient was kept in bed two or three days. The patients were four females and eight males, and their ages were one two and a-half years, seven under 12, and four male adults over 12.

Five cases had secondary rupial ulcers all over the body and were cured within five days, except one case which took six days for the total disappearance of the scabs. Four cases had deep circular granulomatous ulcers below the knee without marked changes in the bone. All these healed within two weeks. The remaining three cases, also tertiary, had deep ulcers on the legs with necrosis and enlarge ment of the bone. These were not appreciably benefited by the treatment, although one of them received a second injection at the end of the third week.

(c) Colombo.-13 cases underwent treatment during the period. The method employed was intravenous injection. The dosage varied from 0:3 to 06 grammes. The various lesions noted and the results obtained were: -

(1) Primary sore disappeared in a few days.

In one

(2) Framboesiform eruption disappeared in a phenomenal manner. week nothing more than a few pigment spots were visible. (3) Silvery furfuraceous desquamation: Not a trace was left in a few days.

(4) Onychia, usually in the form of a Framboesia papule under the nail,

dried up and became painless in two or three days.

(5)

Crab Yaws" affecting the palms and soles show rapid improvement and recovery in a few days without local medication. Cracks and fissures and worm-eaten soles yield to the treatment just as easily.

(6) Subcutaneous fibrous nodules and fascial thickenings show improvement,

but take weeks to diminish in size.

(7) Tertiary ulcerations vielded rapidly to treatment.

(8) Pains in limbs and joints, and headaches yielded quickly.

93111

D