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PUBLIC RECORD OFFICE

Reference :-

C.O. 885

21 PUBLIC RECORD OFFICE, LONDON

ALLY WITHOUT PERMISSION OF THE BE REPRODUCED PHOTOGRAPHIC-

COPYRIGHT PHOTOGRAPH-NOT TO

September an ox, both of which have been subjected to intra-jugular injection of corrosive sublimate and methylene blue as indicated by Major Smeaton. Detailed observation charts for the two animals treated, together with charts* for small animals inoculated from them, are appended, and they without further comments embrace the substance of the report. At the same time, for those who may not wish to study the charts, I consider it advisable to give here a short summary of them with notes.

Summary of Charts with Notes.

Animal, No. 18 (Horse). This was a bay stallion 5 years old and about 14.2 h.h., the property of H. N. Thompson, Esq., Conservator of Forests. It was brought to Olokemeji from an up-country station about the 16th July, 1909, and was then in excellent condition. He was first noticed to be sick on the 4th September, and Mr. Thompson at once wired me offering the horse for. experimental treatment, which I accepted, and the animal arrived Lagos by train on the 8th September. The attached observation chart (No. 16) from last-mentioned date explains the animal's condition. As will also be noticed from it no parasites (tryp.) were found in his blood until the 11th of September, on which date treatment was commenced. As will be seen from paragraph 7 of the conclusion and general remarks in my last report on experimental treatment of the disease, it was men- tioned that a horse had been obtained suffering from a more virulent form, which would afford a valuable contrast with the course of the disease as seen in other animals, as well as with its course when experimentally inoculated into smaller animals. This is the horse referred to. Firstly, it will be readily seen from a perusal of the charts in this and my previous report that the symptoms of the two forms of the disease vary considerably in horses. The dematous swellings on the pendulous portions of the body, filling of the legs, ædema of the muzzle, and the very rapid emaciation of the animal, are all naked-eye appearances which will distinguish this form from what I have previously termed a chronic form of the disease. Secondly, in this case, the parasites in fresh-blood preparations do not show any travelling movements across the field of the microscope, and, thirdly, the course of the disease when compared with "Control" animal (No. 2), vide previous report, is very short. In this case, taking the 4th of September as the date on which he was clinically observed to be sick, the duration of the disease would be 16 days. From my own knowledge, this form seldom lasts longer than from 50-60 days in horses. (Compare duration periods in charts of horses 1-4 of previous report.)

The following inoculations from this animal took place:-

(a) Dog, vide chart No. 17, gave an incubation period of four days followed

by a duration period of 22 days.

(b) Dog, vide chart No. 18, gave an incubation period of six days, duration period seven days. The virulence of this form of the disease when inoculated from horse to dog is much greater than the chronic form, see chart No. 7 (previous report) where the animal went on for 47 days without responding to inoculation. Symptoms, &c., will be readily seen from the remarks column of their respective charts.

(c) Guinea pig, No. 19, showed parasites in its blood after 16 days, and died of the disease on the 5th November, giving a duration period of 55 days.

(d) Guinea pig, No. 20, showed parasites in its blood after an incubation

period of 10 days and died of the disease 19 days later.

Animal, No. 21 (Ox).—This animal was recently brought from Illorin and was in fairly good condition on the 29th September, on which date he came into my possession. His blood on last-mentioned date was swarming with trypanosomes. In my covering letter (66/9) to last report, I drew attention to the fact that I con- sidered more than one ox was necessary to experiment upon, and the animal was obtained for this purpose on the date mentioned. I also mentioned that experi- mental treatment on oxen suffering from a more virulent strain might be tried; and, for this purpose, on the 29th September the animal was given intra-jugularly 3 c.c. of the blood of No. 17 (dog), which died the same day. Unfortunately the ox died of the form of trypanosomiasis it was suffering from prior to inoculation,

• Not printed.

before a reasonable incubation period had elapsed. Treatment was commenced on the same date.

The following inoculations from this animal took place: On the 6th October two grey rats were each given 1 c.c., one grey rat received 3 c.c., and one 2 c.c. All inoculations were made intra-peritoneally. The two receiving 1 c.c. died on the 15th October without parasites being recovered from their blood, the one receiving 2 c.c. died on the same day as it was inoculated from shock, and the one receiving 3 c.c. is still alive and, up to the time of writing, parasites have not been found in its blood.

Conclusions.

Intra-jugular injection of corrosive sublimate and methylene blue as indicated by Major Smeaton had no effect in clearing the blood of parasites or in staying the progress of the disease in any way in the case of horse suffering from a virulent form of trypanosomiasis, vide chart No. 16. The same remarks apply to the treat- ment as applied to an ox, vide chart No. 21.

G. GARDEN,

40719

GENTLEMEN,

No. 2.

Veterinary Officer.

EAST AFRICA PROTECTORATE. COLONIAL OFFICE to THE ROYAL SOCIETY. [Copy to Governor, 6 January, 1910. No. 6. L.F.]

Downing Street, 4 January, 1910.

I AM directed by the Earl of Crewe to acknowledge the receipt of your letter of the 16th of December,* on the subject of a recommendation made by a Conference held at Nairobi to discuss sleeping sickness and stock diseases prevalent in the East Africa Protectorate, to the effect that the Royal Society should be approached to nominate a small Commission for the purpose of working out the distribution and investigating the causes of disease in man and stock in the Protectorate.

2. No communication has been received from the Governor with regard to the recommendation in question; and it is therefore not possible to take any action in the matter at present.

A copy of

your letter will, however, be sent to the Governor for a report.

40719

(No. 26.)

SIR,

•

No. 3.

I am, &c.,

G. V. FIDDES.

EAST AFRICA PROTECTORATE.

THE SECRETARY OF STATE to THE GOVERNOR.

[Answered by No. 12.]

Downing Street, 13 January, 1910.

I HAVE the honour to acknowledge the receipt of Mr. Jackson's despatch,

No. 622, of the 4th of November last, and to request you to furnish me with a full report of the Conference held at Nairobi from the 26th to the 29th of April of last year, to concert measures to prevent the spread of human and animal trypanosomiasis.

The reference to the report contained in your despatch, No. 682, of the 3rd of December,‡ makes it necessary for me to know what course the discussion of stock diseases took.

I have, &c.,

• No. 21 in Miscellaneous No. 238. ↑ No. 23 in Miscellaneous No. 238.

CREWE.

147: not printed.

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